Cenobamate (Xcopri) for Focal Seizures
Cenobamate (Xcopri) for Focal Seizures
August 24, 2020 (Issue: 1605)
The FDA has approved cenobamate (Xcopri – SK Life
Science) for oral treatment of partial-onset (focal)
seizures in adults.
- Drugs for epilepsy. Med Lett Drugs Ther 2017; 59:121.
- M Nakamura et al. Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons. Eur J Pharmacol 2019; 855:175.
- LJ Greenfield Jr. Molecular mechanisms of antiseizure drug activity at GABAA receptors. Seizure 2013; 22:589.
- R Sharma et al. Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate. Eur J Pharmacol 2020; 879:173117.
- SS Chung et al. Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology 2020; 94:e2311.
- GL Krauss et al. Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial. Lancet Neurol 2020; 19:38.
- MR Sperling et al. Cenobamate (YKP3089) as adjunctive treatment for uncontrolled focal seizures in a large, phase 3, multicenter, open-label safety study. Epilepsia 2020; 61:1099.
- Approximate WAC. All available tablet strengths cost the same. WAC = wholesaler acquisition cost or manufacturer's published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly. August 5, 2020. Reprinted with permission by First Databank, Inc. All rights reserved. ©2020. www.fdbhealth.com/drug-pricing-policy.
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Title: Cenobamate (Xcopri) for Focal Seizures
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