Secnidazole (Solosec) for Bacterial Vaginosis
Secnidazole (Solosec) for Bacterial Vaginosis
March 26, 2018 (Issue: 1543)
The FDA has approved secnidazole oral granules
(Solosec – Symbiomix/Lupin) for single-dose treatment
of bacterial vaginosis (BV) in adult women.
- P Nyirjesy and JR Schwebke. Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment. Future Microbiol 2018 Jan 12 (epub).
- JE Allsworth and JF Peipert. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet Gynecol 2007; 109:114.
- Drugs for sexually transmitted infections. Med Lett Drugs Ther 2017; 59:105.
- CS Bradshaw and JD Sobel. Current treatment of bacterial vaginosis – limitations and need for innovation. J Infect Dis 2016; 214 (Suppl 1):S14.
- SL Hillier et al. Secnidazole treatment of bacterial vaginosis: a randomized controlled trial. Obstet Gynecol 2017; 130:379.
- JR Schwebke et al. A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. Am J Obstet Gynecol 2017; 217:678.
- JM Bohbot et al. Treatment of bacterial vaginosis: a multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole. Infect Dis Obstet Gynecol 2010 Sep 15 (epub).
- SE Chavoustie et al. A phase 3, multicenter, prospective, open-label study to evaluate the safety of a single dose of secnidazole 2 g for the treatment of women and postmenarchal adolescent girls with bacterial vaginosis. J Womens Health (Larchmt) 2018 Jan 11 (epub).
- HS Pentikis et al. Lack of a pharmacokinetic interaction between SYM-1219 granules containing 2 grams of secnidazole and a combined oral contraceptive in a phase 1, randomized, open-label study in healthy female volunteers. Adv Ther 2017; 33:2229.
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