Delafloxacin (Baxdela) - A New Fluoroquinolone Antibiotic
March 26, 2018 (Issue: 1543)
The FDA has approved delafloxacin (Baxdela –
Melinta), an anionic fluoroquinolone antibiotic, for oral
and parenteral treatment of adults with acute bacterial
skin and skin structure infections (ABSSSIs), including
those caused by...more
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- W O'Riordan et al. A comparison of the efficacy and safety of intravenous followed by oral delafloxacin with vancomycin plus aztreonam for the treatment of acute bacterial skin and skin structure infections: a phase 3, multinational, double-blind, randomized study. Clin Infect Dis 2018; in press.
- S McCurdy et al. In vitro activity of delafloxacin and microbiological response against fluoroquinolone-susceptible and nonsusceptible Staphylococcus aureus isolates from two phase 3 studies of acute bacterial skin and skin structure infections. Antimicrob Agents Chemother 2017; 61:e00772-17.
- Alternatives to fluoroquinolones. Med Lett Drugs Ther 2016; 58:75.
- JS Litwin et al. A thorough QT study to evaluate the effects of therapeutic and supratherapeutic doses of delafloxacin on cardiac repolarization. Antimicrob Agents Chemother 2015; 59:3469.
- J Ferguson et al. Assessment of phototoxicity potential of delfloxacin in healthy male and female subjects: a phase 1 study. Poster presented at ICAAC/ICC, San Diego, CA, Sept 17-21, 2015. Poster F-1198a.
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